ABSTRACT
Titanium is a popular material choice across orthopaedic and dental implant industry, and surface modifications of titanium-based implants to achieve enhanced bioactivity and local drug release have been widely explored. Among these modifications, to achieve local elution of potent therapeutics, electrochemically anodized titania nanotubes (TNTs) stand out, attributed to tailorable drug loading/release, established in vitro and in vivo investigations and ease of further modification. This chapter discusses and details the scope of TNTs-modified, Ti-based implants towards local drug delivery applications. Various therapies from TNTs/Ti implants are discussed and detailed with respect to therapeutic efficacy and challenges that must be bridged to achieve the clinical translation of nano-engineered therapeutic Ti implants.
