ABSTRACT
Bone fractures are the most common form of hospitalized trauma. The process of bone healing is complex and involves both biological and mechanical aspects. For this purpose, during the last decade, simulation and modeling of bone healing have been used to understand the details and mechanisms involved and to allow the development of more accurate and rational strategies for the treatment of fractures and to accelerate healing. Many computational models have been established to predict callus formation due to mechanobiological rules. Advances in the mechanobiology of bone enable the understanding of the mechanical response to loading by individual cells, as well as tissue differentiation during events such as fracture healing. The present paper aims to review some of these models of bone regeneration and remodeling.
