Nanomanufacturing involves fabricating nanoscale components or materials and integrating their features as well as their resolution into systems that are engineered as desired. It is possible to achieve novel characteristics, features and functionalities in nanoscale manufacturing with utmost precision and control in the nature of processes as well as the materials. In order to achieve these, it is also essential to overcome the challenges that come with nanomanufacturing. These challenges of nanomanufacturing include cost-effectiveness, quality obtained in case of the product, functionality that is desirable, repeatability of the process and scale of the production. Moreover, with the advancement in the fields of materials, nanotechnology as well as the manufacturing technology and the growing industrial demands, it is extremely essential to cater the demand. This is only possible when the issues related to nanomanufacturing are addressed. Therefore, keeping the above aspects in mind, this chapter is written to elaborate on the various challenges and opportunities in the nanomanufacturing field.