ABSTRACT
Mangifera indica L., known as mango, is an evergreen tree with characteristic edible fruits belonging to family Anacardiaceae. It is characterized by rich nutritional value and medicinal aspects for human health. Traditionally, it has been used an aphrodisiac, astringent, appetite stimulant, diuretic, anti-asthmatic, and to relieve gastrointestinal symptoms, sore throat, and dysmenorrhea. Several pharmacological activities such as anti-diabetic, antioxidant, neuroprotective, immunomodulatory, antimicrobial, anti-inflammatory and antioxidant have reported in recent years. Numerous bioactive compounds as xanthonoids, flavonoids, tannins, triterpenoids, and phenolic acids have been isolated from different types of mango extracts. Most of them exploited anti-diabetic properties acting on α-amylase, α-glucosidase, dipeptidyl peptidase-IV, pancreatic β cells, insulin sensitivity, and antioxidant defense mechanisms. This book chapter is designed to pile up all information regarding the potential role of M. indica in the management of diabetes mellitus. We discuss the in vitro and in vivo anti-diabetic studies of different extracts and isolated compounds. Interestingly, we focus on the molecular mechanism, pharmacological action, and docking investigations that have been performed on isolated compounds. Hopefully, this chapter presents a source for researchers to develop a new plant-derived anti-diabetic agent with a promising efficacy and low side effects.
