ABSTRACT
Infertility is a major problem in Western countries, but also—either less expressed or less registered—in all human societies around the world. Chromosomal aberrations identified in these products of conception (PoCs) can be important to make such couples better understand why an abortion has happened, and also as they can be a hint on a cryptic gonadal mosaicism being present in male or female partner. In some settings, DNA extraction from PoCs and subsequent chromosome- microarray, multiplex ligation-dependent probe amplification, or simple STR -analyses may be used to find genomic imbalances, that have being causative for the abortion. As the available amount of PoC-material normally is restricted, at least two- to multicolor-FISH settings are recommended.
