ABSTRACT
The possibilities to obtain a diagnosis on the reasons for an abortion are still by far not exhausted in routine settings. During the meiosis process, there is not only a reduction of chromosome number to a haploid set but also the aleatoric segregation of maternal and paternal chromosomes, and genetic combinations in the offspring due to exchange of genetic material in maternal and paternal homologues through recombination. The reduction in chromosome number is pivotal to restore diploid chromosome complement in the subsequent generation through the union of two gametes during sexual reproduction, ensuring continuity of the species. Errors in homologous chromosome segregation during either meiosis or mitosis can lead to an aberrant chromosome number, which is termed aneuploidy this could occur in the postnatal, prenatal, or preimplantation stage, having significant clinical consequences. Chromosomal alterations could be categorized as numerical or structural and could involve more than one chromosome.
