ABSTRACT
Fluorescence in situ hybridization (FISH) is a technological basis of interphase molecular cytogenetics. Interphase FISH is found useful for a wide spectrum of applications from molecular cytogenetic diagnosis to interphase chromosome biology. Molecular cytogenetic analysis is an integral part of the research and medical care in clinical/medical genetics, reproduction, oncology, neurology, psychiatry, pediatrics. In the diagnostic context, the availability of single-cell molecular cytogenetic analysis via visualization is a striking advantage offered by interphase FISH. Interphase FISH-based technologies may help to gain further understanding of causes and consequences of CIN and chromosomal rearrangements. Therefore, interphase molecular cytogenetics using FISH-based approaches represent an important part of studying genetics/genomics, cellular and molecular basis of intercellular or interindividual diversity and diseases.
