ABSTRACT
Recently Field Effect transistor (FET)-based biosensing applications have gained significant attention due to the demand for quick and accurate diagnosis of different enzymes, proteins, DNA, viruses, etc; cost-effective fabrication process; portability and better sensitivity and selectivity compared to the existing biosensors. FET is basically a three-terminal device with source, drain, and gate terminals. Basically, the gate terminal controls the current flow between the source and drain terminals. In FETs, first, a nanogap is created in the oxide layer or in the gate by etching adequate materials. When the biomolecules are trapped inside the nanocavity then the surface potentials change and also the threshold voltage varies. As a result, the output current also changes. Finally, by measuring the changes in the threshold voltage or the device current, one can easily detect the biomolecules easily.
