ABSTRACT
The past outbreak of the new SARS-CoV-2 coronavirus and the fast spreading rates of the COVID-19 pandemic around the globe presented a global emergency that needed to be tackled by vaccine development. This chapter analyzes the different vaccine platforms that have been used to generate safe and efficacious vaccine candidates against SARS-CoV-2. It covers SARS-CoV-2 biology and immunology, focusing on the characteristics on which vaccines are based. Then, the different platforms are discussed and organized depending on the technology used. Vaccines based on RNA, from which the complete biomanufacturing process is explained, viral vector, whole virus, and protein sub-unit vaccines are reviewed. This chapter finally enables the reader to understand the overall different approaches undertaken to create a vaccine candidate for COVID-19 and the main challenges for their industrial production.
