Corona virus disease 2019 (COVID-19) is caused due to corona virus that spreaded worldwide and became a pandemic. Currently several studies are going on to search appropriate drugs or vaccine to prevent these disease. To search the plant based medicines which have antiviral and Immunomodulatory properties that prevent the viral infected disease. Liquorice root is used worldwide as an herbal medicine. This root commonly known as sweet wood, Mulethi or Yashtimadhu. Various active components like glycyrrhizin, isoflavonoids, triterpenoids, sterol, amino acid etc that have antiviral and immunomodulatory properties. Liquorice has the ability to reduce the expression of proinflammatory cytokines, interleukin, TNFα, and stimulate the secretion of lymphocyte. SARS-CoV2 and SARS-CoV have the same receptor ACE2. Glycyrrhetinic acid helps to down regulate the expression of angiotensin-converting enzyme 2 (ACE2) in lungs and prevent the entry of virus. Liquorice polysaccharide helps to modulate our immune system by the activation of CD4 T cell. In this present study we reviewed about the Immunomodulatory effect of liquorice that helps in healthy living in pandemic situation.