ABSTRACT
Many plants and herbs have been traditionally used in the Middle East and some are still used today to treat various diseases. Ammi visnaga, commonly known as khella, is a well-known example of a medicinal plant used traditionally in the region, and its pharmacological action has been scientifically explored in various studies. Preclinical and clinical studies immensely investigated its active phytochemicals, namely khellin and visnagin.
The plant extract and active constituents of khella were found to have antispasmodic, anti-inflammatory, antimicrobial, and vasodilatory effects. Moreover, they proved efficacious in treating renal colic, urolithiasis, and urinary tract infections. They were also found beneficial in various topical applications such as wound healing, vitiligo, psoriasis, and poisonous bites management. However, it should be used with caution as it can lead to elevation of liver enzymes, photosensitive reactions, and oxytocic effect.
