ABSTRACT
Natural bioactive compounds have a wide range of structures and functions, making them a great source of molecules for developing nutraceuticals, functional foods, and food additives. Some of these chemicals, such as polyphenols, may be found in large concentrations in nature. In contrast, others can only be found at extremely low levels, necessitating enormous collection, and their structural variety and complexity make chemical synthesis costly. Because of the inherent challenges in screening and manufacturing these chemicals, sophisticated methods have been developed. The most frequent extraction methods are traditional liquid-liquid or solid-liquid extraction, while sophisticated extraction methods include pressurized-liquid extraction, subcritical and supercritical extractions, and microwave- and ultrasound-assisted extractions. Furthermore, these extraction procedures have been enhanced by preceding stages (enzyme- and immediate controlled pressure drop-assisted extractions), which aid in the release of chemicals from the matrix. These technologies may give a new way to increase the production of compounds for use as nutraceuticals in the years ahead.
