An efficient disposal or utilization of mine waste and tailings is essential to reduce the impact on environment. There are wide range of applications for mine waste and tailings in civil, mining, agriculture and infrastructure projects. This chapter tries to consolidate the important applications of mine waste and tailings in various applications with some new thoughts. Utilization of mine waste and tailings in bricks, concrete, etc., are discussed. Other relative new technologies like soil stabilization using mine tailings, alteration of thermal conductivity of soil, leakage prevention through geomembranes using mine tailings and water balance covers using mine tailings and waste rock are also discussed in this chapter.