ABSTRACT
Despite targeted therapies, such as an arsenal of antibiotics, sepsis therapy remains a global concern. Besides their ineptness in addressing sepsis-related inflammation in patients, antibiotic overuse promotes the rise of multidrug-resistant microbes. The herbal formulations that contain bioactives are all-important in the traditional system of medicine for sepsis treatment. Within the host, these bioactives quell or fend off the intruding bacteria along with the production of inflammatory mediators. Therefore, to deduce the antimicrobial potential of these bioactive in the treatment regime against sepsis, we must unravel two important aspects. First, to gather clinical data regarding their immunomodulatory and immunosuppressive effects on the host immune system. Second, to unravel the molecular mechanisms involved in their anti-inflammatory effects. In this chapter, we have attempted to recapitulate the findings from the in vitro, in vivo, and clinical studies on the anti-sepsis activities of various plant extracts and bioactives isolated from them. In conclusion, this information may pave way for the development of promising plant-based anti-sepsis antimicrobials.
