ABSTRACT

Delivering drugs using the inhalation route to the lungs is the foundation of the everyday clinical management of patients with airway diseases. The inhaled route, as opposed to systemic drug administration, allows key therapeutic benefits. Targeting the drugs to the site of action in the lungs achieves a quicker onset of action, a reduction in the dose of drug used, and an improved therapeutic ratio (efficacy to adverse event ratio). The global pandemic has seen a seismic need for us to understand aerosol science, for example, infectious aerosols and therapeutic aerosols. In this chapter we discuss the physiochemical factors that control the transport, delivery, and deposition of inhaled drug within the lungs.