ABSTRACT
Curcumin is derived from the dried rhizome of turmeric, and it is a hydrophobic phenol that performs various pharmacological actions such as anti-inflammatory, anti-microbial, antioxidant, anti-psoriasis, antidiabetic, and anticancer. However, curcumin has low bioavailability problems which accompany low water solubility and >90% of the drug degrades rapidly in an alkaline medium when administered orally. The topical administration of the medication will mitigate the problem and prevent metabolism from occurring first-hand and thus supply it to the target location. The CUR-loaded nanocarrier is an excellent novel strategy. It also allows controlled release and helps to improve the permeation of the medicinal product through the structural membrane of the skin, stratum corneum. Nanocarriers are able to promote topical delivery as monotherapy or in combination, of antiacne medication by a variety of mechanisms, like occlusive, which promote skin hydration and thereby reduce the frequency of the dosage, the follicular targeting, and protect the active labile from degradation. In fact, smart nanocarriers may carry the anti-acne cargo in non-target locations to prevent unwanted results because certain triggers are on the site.
