ABSTRACT
Alzheimer’s disease (AD) is the most common dementia in which there is a loss of neurons that leads to cognitive impairment and memory loss. Amyloid plaques and neurofibrillary tangles are pathological hallmarks of AD. There is no cure for AD at present, the synthetic drugs available in the market only provide symptomatic relief. Moreover, they also have several side effects, so there is a need to develop medications that can prevent or cure AD. In the last two decades, researchers have shown the neuroprotective role of several plant bioactives such as curcumin, resveratrol, epigallocatechin-3-gallate, quercetin, etc. in AD. Using these compounds, it has become possible to target multiple pathophysiology of AD, but the problem is poor solubility and low bioavailability. Also the presence of the blood-brain barrier (BBB) restricts the entry of compounds inside the brain. To overcome these, nanotechnology has been explored. By preparing nanosized particles of plant 140bioactives, it becomes possible to achieve targeted delivery to the brain. This chapter discusses several plant bioactive compounds that shows effect in AD along with its mechanism of action, in vitro and in vivo studies. The nanoformulations prepared using these bioactives and its effect observed in AD have also been discussed.
