ABSTRACT
Solid-state fermentation (SSF) has made credible advances in biotechnological industries for their potential applications especially for bioactive metabolites and pharmaceutical products. After the detailed understanding of biochemical manipulations particularly in the field of fermenter modeling and designs, SSF have been successfully continued for the scale-up and commercialization of desired products. In the present scenario, the large-scale production of bio molecules produced by natural products is the need of the hour. Henceforth, SSF showed intensive application in the field of biotechnology for the large scale production of pharmacologically active molecules along with extensive stability of the desired product at economical level. In this chapter, we highlighted various technological interventions of the solid-state fermentation (SSF) for the enhanced production of endophytic bioactive secondary metabolites and various optimizing strategies that are mandatory in the coming times for their growth and development.
