ABSTRACT
The binding of Immune Complexes (ICs) to FcγRs may lead to either activation or suppression of inflammatory cells depending on the type of FCGR gene expressed, and IC-induced cellular activation or suppression has been documented in many disease processes. ICs may also precipitate in tissues, leading to local inflammation or organ damage, influx of inflammatory cells and complement activation. Methods for IC detection are typically based on their physicochemical properties, such as their size, antibody class, affinity for specific cellular receptors and susceptibility to phagocytosis by macrophages [13]. A variety of methods are available for isolation of ICs or identifying elements associated with but not directly identifying ICs and are summarized in Menikou et al. Full gene names for UniProt proteins were determined by InterMineR. Individual proteins were classified using string matching as keratin, trypsin, complement, albumin, fibrinogen, immunoglobulin, other, contaminant and influenza.
