ABSTRACT
Advancements in science and civilization are still not enough to catch hold of incurable diseases. A living example is cancer, being the 2nd largest disorder that takes many lives each year. According to world cancer data reports, in the last four years (2016–2020), cancer has subdued cardiovascular disease to become the second-largest disease. Unfortunately, the drugs there in the market produce some severe side effects, of which several are irreversible. Thus, raising the potency of drugs under investigation should not be the only objective; instead of searching for ways to eclipse the side effects must be considered seriously. The bio-molecular components or events thought to be
responsible for cancer are epidermal growth factor receptor (EGFR), histone deacetylase (HDAC), tubulin, proteasome, topoisomerase, PI3K/AKT/ mTOR signaling PT W. The emerging trend in anticancer therapy is the supplementation of nutrients of therapeutic values. OM polyunsaturated fatty acids (PUFAs) have attracted so many researchers to work on their innumerable biological effects. Owing to their cell signaling role, maintenance of fluidity of membranes can contribute to the anti-inflammatory and anti-nociceptive effects common in cancer patients. The risk of cancer is significantly reduced using modulating COXG-2 PT W. They may serve as inhibitors of the 5-LOXG enzyme; even suppression of 20-HETE biosynthesis could slow down tumor progression in animal models. The real benefits of PUFA supplementation in cancer requires to be investigated further. However, preclinical study reveals that this class of compounds presumably alters the central PT W underlying complicacies secondary to cancer, thus indicating an exciting research area to be explored.
