ABSTRACT
Over the past few decades, exosomes have emerged as a novel mechanism to carry and transport bioactive molecules to distant cells. In addition to proteins, nucleic acids, and enzymes, exosomes have recently been shown to contain and deliver membrane-derived lipid mediators such as prosta- glandins, leukotrienes (LTs), and pro-resolvins. These lipid mediators play a significant role in the immune system, hence immune-mediated cancer. Tumor exosomes have been shown to contain higher amounts of bioactive lipids as compared to healthy cells which led to their candidacy for cancer diagnostic or prognostic marker. In addition, bioengineering of exosomes could be employed to package lipid moieties to target cancerous cells as therapeutics.
