ABSTRACT
Immunotherapy has presently become the primary tool for fighting cancer and has become a landmark for oncology treatment. Regular cancer treatments are now performed by using this technique as it can successfully destroy tumor cells. The immunological approach is now being used as a powerful weapon that includes T cell characterization and other innate and adaptive immune responsive cells such as Natural killer (NK) cells, Dendritic (DC) cells, macrophages and B cells, which are involved in regulating tumor progression and immunotherapy responses. In this review, we mainly focus on the major applications and categories of immunotherapy, their history of development, recent findings on tumor-infiltrating immune cells in human cancers, and their connections with immunotherapy, future perspectives, and challenges.
