ABSTRACT
Membrane-type matrix metalloproteinases (MT-MMPs) affect several diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. These MMPs are expressed on the cell membrane. Instead of MT-MMPs, researchers are primarily working to develop alternative MMP inhibitors, such as collagenase and gelatinase inhibitors. As a result, there is much scope for developing MMP-14 inhibitors. Potential MMP-14 inhibitors can be designed using ligand- and structure-based molecular modeling techniques and X-ray crystallographic data. In this chapter, although not a lot of information is available on other membrane-type MMPs, the majority of molecules having potential roles of MMP-14 and their inhibitors will be discussed.
