ABSTRACT
Gelatinases, also called matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), have been targets of choice for drug development for many years. Therefore, their inhibitors may serve as an important weapon against cancer, neurological conditions, and lung diseases, as well as cardiovascular disease prevention and treatment. In this chapter, the structure, as well as the function of gelatinases, are discussed. Various gelatinase inhibitors with different zinc-binding groups (ZBGs) and non-zinc binding characters are illustrated. This chapter summarizes potent gelatinase-selective inhibitors. The prime objective is to give an overview and detailed insight into these gelatinase inhibitors to the scientific community to allow further development. This is a part of the continuous efforts toward the identification of potent gelatinase-selective inhibitors. This chapter provides crucial insights to explore inhibitors for future endeavors to speed up drug discovery efforts.
