ABSTRACT
Globally, liver cancer is one of the severe health problem affecting both men and women. A large number of scientific studies suggested dysregulation of signaling cascades as one of a major characteristics of liver cancer. Therefore, targeting such dysregulated signaling pathway will be a crucial therapeutic strategy. The marine ecosystem represents 70% of the earth and is considered a reservoir of bioactives with various pharmacological properties such as proteins, peptides, polysaccharides, polyunsaturated fatty acids, phenolics, carotenoids, minerals, vitamins, and others. Numerous in vitro and in vivo studies have demonstrated the pharmacological activities of these marine phytochemicals such as antioxidant, cardioprotective, hepatoprotective, neuroprotective, immunomodulatory, antidiabetic, anti-obesity, anti-inflammatory, and anticancer, among others. A vast number of studies demonstrated the hepatoprotective effect of marine phytochemicals for treating liver cancer. However, none of them has been clinically approved for therapeutic use. This chapter describes the major marine phytochemicals that are reported to exert beneficial effects in experimental liver cancer treatments.
