ABSTRACT
The development of low-cost and convenient model organisms, cutting-edge molecular biology, omics technology, and machine learning is aiding the bioprospecting of new antimicrobial medications and the discovery of new therapeutic targets. Antibiotic resistance has been the subject of countless resolutions and recommendations as well as numerous regenerated reports, but this has been of no advantage since the spread of antibiotic resistance is unstoppable. The phytochemicals were discovered to be effective against a wide range of microbes when used in combination or conjunction with conventional antibiotics. Heimdallarchaeota and Lokiarchaeota, two evolutionarily relevant archaeal phyla previously unknown to have BGCs, were discovered to also have potentially novel BGCs. Infectious agents causing upper respiratory infections affect the upper respiratory organs of the human respiratory system including sinuses and throat infections and other frequently reported illnesses such as common cold, sinusitis, meningitis, sore throat, cough, pneumonia, and Covid-19.
