ABSTRACT
Rhubarb, an herbaceous perennial that belonged to the family Polygonaceae, has been a plant of various uses for human consumption worldwide. Rhubarb is regarded as a potential anti-cancer compound in Traditional Chinese Medicine. This study is to evaluate rhubarb and its six major anthraquinone derivatives’ effectiveness in treating lung cancer, through in vitro (MTT cytotoxicity assay, FACS Annexin V/PI assay, Western blot assay, Boyden chamber assay) and in vivo (A549 xenograft in mice and enzyme-linked immunosorbent assay) experiments. Possible results are deduced, interpreted, and discussed.
