ABSTRACT
In this paper, a synthesis routine of akuammicine is proposed. The akuammicine is synthesized by indoles within a few steps. The chirality of carbon 13 is ensured by Chiral HPLC Columns technology, which is the focus of the whole synthetic analysis. What's more, the two rings of akuammicine are generated by the Diels-Alder reaction and Heck reaction, which is the innovation of this approach. Akuammicine is a kind of indole alkaloid from akuamma tree seed extract and it can treat various diseases, such as malaria, dysmenorrhea, and gastrointestinal diseases. Therefore, it is of great significance to study the rapid and effective synthesis method of akuammicine for the medical industry and even the future development of human beings.
