ABSTRACT
Recently, the number of medical applications using nanoparticles as a drug delivery system and imaging carrier has grown massively. Due to their physicochemical characteristics, drug encapsulation performance, capacity for drug release at the target site, elevated permeability, prolonged half-life, and most importantly, their ability to reduce side effects that are frequently associated with traditional medicines, these particles have a chance of being effective in the health centre. They can address the problems of standard medications, such as poor targeting and less permeability. Since lipid-based nanoparticles are the least poisonous and biodegradable for usage in in vivo applications, they stand out among various nanomaterials. LNPs have been shown to reduce the toxicity of several medications by changing the biodistribution of the medications away from susceptible organs. Nanoparticles made of lipids have also demonstrated success in molecular imaging. They serve as cutting-edge contrast agents and offer a viable method for making non-invasive diagnoses. They successfully produce customized contrast agents that are more sensitive and focused than those already on the market. They possess all the qualities necessary for optimal imaging, including biocompatibility. One of the major properties of these nanoparticles is that they can cross blood-brain barriers, which also helps to make them an effective way to deliver drugs. This study primarily concentrates on diverse lipid-based nanoparticle kinds, typical manufacturing techniques, administration routes, and their use in medical imaging.
