ABSTRACT
Coronaviridae is a family of a multitude of enveloped, positively sensed ssRNA viruses that infect the respiratory system of different animals like humans, bats, and others. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a one-of-a-kind coronavirus that is the root cause of the extremely contagious coronavirus disease 2019 (COVID-19) pandemic. To date, millions of cases and fatalities have placed a strain on healthcare systems worldwide. In COVID-19, the mortality rate for elderly individuals with pre-existing chronic conditions is significant. There are no effective therapeutic methods for COVID-19 prevention or therapy at the moment. Consequently, finding effective treatments is crucial. Terpenes are isoprene-based, naturally occurring compounds with a high degree of chemical diversity and a variety of medicinal benefits. This class of natural compounds has tremendously aided in the development of new medicines. Terpenoids and terpenoid derivatives are traditional medications derived from medicinal plants and have a variety of therapeutic uses. The natural oils of plants are the primary source of their existence. They currently make up a wide range of natural compounds that could be employed as a foundation for developing powerful pharmacotherapeutic drugs or as a source for novel pharmaceuticals. There is no deadline for the global COVID-19 vaccination campaign, which has already started and is anticipated to advance gradually. Some people choose not to get vaccinated for personal or medical reasons. In addition, some population groups, notably the younger ones, would be the last to get their shots. A method that is safe and reasonably easy to abate infection in those people is to deliver a natural antiviral treatment with few aftereffects as a prophylactic treatment, alone or in combination with immunizations. This chapter's goal is to provide a thorough summary of terpenes' antiviral activity, focusing on SARS-CoV-2. It also aims to emphasize the virus-fighting mechanism of terpenes.
