ABSTRACT
Rotavirus is a common human pathogen that causes significant morbidity and mortality, particularly in children under 5. Current approaches for managing rotavirus infection are limited, highlighting the need for alternative treatments. Medicinal plants and herbs have long been used as natural remedies for various ailments, and their potential in combating rotavirus infection is being increasingly explored. This paper discusses the mechanisms of rotavirus infection and transmission and the current challenges in its management. It highlights the various approaches for treating rotavirus infection, including using phytochemicals derived from medicinal plants. Specifically, these plants’ polyphenols, alkaloids, and terpenoids have shown promising antiviral properties against rotavirus. These secondary metabolites interfere with viral attachment, replication, and protein synthesis, inhibiting viral infectivity. Additionally, plant extracts have been found to modulate immune responses, restore cell signaling, and repair intestinal damage caused by rotavirus infection. The book chapter concludes by emphasizing the need for further research on the mechanisms of action of these plant-derived compounds and their potential use in vaccine development. Understanding the therapeutic potential of medicinal plants in combating rotavirus infection can pave the way for developing effective and safe antiviral therapies.
