ABSTRACT

Ankaflavin was a yellow pigment of monascus, which might have anti-obesity effects in recent studies. In this paper, the effect of ankaflavin on fatty acid content in muscle of obese mice was studied by the Gas Chromatography with Flame Ionization Detection (GC-FID) method. The results showed that ankaflavin did not significantly reduce the body weight and BMI of obese mice induced by a high-fat diet when the mice's daily effective dose was about 2.0 mg of ankaflavin per kilogram of body weight and the experiment was carried out for 12 weeks. However, ankaflavin could significantly reduce blood uric acid levels in obese mice. What is more, the results of GC-FID showed that ankaflavin could significantly reduce the contents of C14:1n5, C16:0, C18:0, and C18:1 in the muscles of obese mice, while increasing the contents of downstream metabolites C20:1n9 and C20:3n6. The above data provide a reference for an in-depth study of the functions of ankaflavin.