ABSTRACT
Xylitol is a natural polyol and is most widely known for its sugar substitute properties in diabetic patients; it is also used against an oral bacterial population. Xylitol is one of the most expensive polyol sweeteners and considerable attention in the food and pharmaceutical industries. This chapter describes the microbial screening and optimization of medium composition, process variables for xylitol production by Candida parapsilosis strain Bradykinin receptor (BKR1) using Plackett-Burman (PB) and Response Surface Methodology. The PB screening design is applied for knowing the most significant nutrients enhancing xylitol production. Plackett-Burman experiment design showed a wide variation in xylitol production. Optimization of the medium components and process parameter plays a vital role in fermentative production of xylitol, a natural polyol and important pharmaceutical constituent. The multiphase stirred tank reactor has the ability to produce 0.55 g/g yield of xylitol against xylose in the indigenously isolated Candida parapsilosis strain BKR1.
