ABSTRACT
Gallstones, granulomatous hepatitis, liver abscess, portal vein thrombosis and hepatic amyloidosis are more frequently observed in Crohns disease (CD), while PSC, autoimmune hepatitis (AIH) and AIH/PSC overlap syndrome are more prevalent in ulcerative colitis (UC). The estimated prevalence of PSC in Europe is 2 to 7 cases per 100,000 habitants, and it is a relatively rare disease in Brazil. In patients with PSC, in turn, UC and CD are observed in 60 to 80% and 13% of cases, respectively. Patients with PSC usually present predominant elevation of alkaline phosphatase and gamma-glutamyl transpeptidase. The presence of PSC should be investigated in all patients with IBD and unexplained cholestasis in the absence of antimitochondrial antibody. Sulfasalazine and, less frequently, 5-ASA can cause hepatocellular or cholestatic acute hepatitis, and also granulomatous hepatitis. Cyclosporine, in turn, has been associated with the occurrence of cholestatic acute hepatitis.
