ABSTRACT
Inflammatory bowel disease (IBD) includes two major disease groups: ulcerative colitis and Crohns disease. In the resolution phase of colitis, there is reduced activity and lesions to the crypts, regeneration and remodeling of crypts, and, last, the disappearance of the basal lymphoplasmacytic infiltrate. In such cases, the pathologist examines surgical specimens in advanced stages, with segmental mucosal lesions, and with areas of partial or transmural involvement of the bowel. Other common histopathological features include obliterating vascular lesions, nerve hypertrophy and deep enteritis/cystic colitis. Intraepithelial neoplasia (dysplasia) is a glandular neoplastic proliferation that can occur in IBD patients, but with macroscopic and microscopic features that distinguish it from an adenoma. Considering that the adenocarcinoma invasion can take place associated with intraepithelial neoplasia with relatively discreet morphological changes, high-grade intraepithelial neoplasia is diagnosed in colitis based on less severe abnormalities than the criteria of intraepithelial neoplasia of adenomas.
