ABSTRACT
The development and use of an increasing number and variety of natural, transgenic, induced mutant, and genetically engineered mouse, knockout and mouse/human hybrids models have been imperative in understanding the gene-driven cellular and molecular mechanisms and pathophysiological manifestations (phenotypes) of several disorders that are similar to mice and humans. This chapter describes the use of mouse models in understanding cancer and infectious diseases. Cancer is one of the most exploited areas of research, however, due to a lack of understanding of cancer pathophysiology, no promising drug is available so far which is permanently able to cure cancer. Chemical agents such as factory pollutants or chemical carcinogens are known to be the cause for more than 80% of all cancers and thus they can be used to induce cancer in animal models. Necrotizing soft tissue infection or thigh infection is a disastrous infection of the subcutaneous tissue and underlying fascial layers.
