ABSTRACT
Antimicrobial nanoparticles (NPs) offer many distinctive advantages such as reduced toxicity, potential to overcome resistance and lowercost over conventional antibiotics. Various nano sized drug carriers are also available to efficiently administer antibiotics by improving pharmacokinetics and pharmacodynamics by reducing the adverse effects of antibiotics. This chapter introduces employing nanotechnology as a new paradigm in controlling infectious diseases, especially in overcoming antimicrobial drug resistance, in the context of research and clinical prospective of this novel and promising strategy. Polymeric-based nanoparticles can act as carriers for a wide range of materials including protein or DNA vaccines. Surface morphological study was carried out using field-emission scanning electron microscopy (SEM) image. X-ray photoelectron spectroscopy (XPS) was used for contribution of Zn and O elements. While most of the nanoparticle based antimicrobial drug delivery systems are currently in preclinical development, several have been approved for clinical use.
