ABSTRACT
This chapter discusses the development of redox nanoparticle therapeutics. It includes the synthesis of redox polymers, the preparation of redox nanoparticles, and the treatment of oxidative stress injuries by using redox polymer therapeutics. One promising strategy to improve the efficiency of nanotherapy is “on-off regulation,” whereby the nanoparticle is dormant in non-target tissue and is activated in the target area, thus improving treatment outcomes and decreasing adverse effects. The intestinal mucosa of patients with inflammatory bowel disease has been reported to be characterized by reactive oxygen species overproduction and an imbalance of important antioxidants, leading to oxidative damage. Redox nanoparticles (RNPs) have been shown to have therapeutic effects in other disease models. Both RNPs have been reported to suppress excessive inflammation after cerebral hemorrhage induced by focusing ultrasound beam radiation coupled with fluorocarbon microbubbles after intravenous administration.
