ABSTRACT
For centuries, mushrooms have been considered one of the important components of food resources and folk medicine. This is based on their high nutritional values as well as many functional bioactive compounds. Mushrooms have been cultivated in greenhouse for sustainable supply as traditional cultivation practice for many years. However, this system has many limitations in terms of slow cell growth, ease of contamination, and low yield of bioactive metabolites. In addition, as an open cultivation system, controlling culture sterility during long-term cultivation is challenging and thus cannot comply with the current Good Manufacturing Practice (cGMP) which is required for production of pharmaceutical products. Thus, nowadays, submerged cultivation systems in closed bioreactor systems become a more attractive methods for the production of mushroom bioactive molecules. This chapter provides the latest information about mushroom cultivation systems.
