ABSTRACT
Salvia mirzayanii Rech. f. and Esfand is an endemic, herbaceous, medicinal and aromatic plant belonging to the Lamiaceae family. The plant grows in the central and southern parts of Iran as a biennial or perennial flowering herb and is broadly used in folk medicine. S. mirzayanii is also known as Iranian Sage, Moor-e-Talkh, or “Marv-e-Talkh” in local areas. It is a traditional medicinal plant used in management of gastrointestinal diseases, skin infections, spasms, inflammations, and weakness by people from the native southern regions of Iran. S. mirzayanii is used in food preparations, cosmetics, drugs, and perfumery industries mainly due to presence of active essential oils. The essential oils in Salvia are classified into oxygenated monoterpenes, monoterpene hydrocarbons, diterpenes, and sesquiterpene hydrocarbons. 246Linalool, spathulenol, δ-cadinene, cubenol, β-eudesmol, α-cadinol, linalyl acetate, and α-terpinyl acetate are the significant components found in essential oil of the plant. The sesquiterpenes present in S. mirzayanii are spathulenol, teuclatriol and bicyclogermacrene and flavonoids such as chrysoeriol, cirsimaritin and salvigenin. The plant has many pharmacological activities such as immunomodulatory activity, antimicrobial activity, antidepressant activity, antioxidant activity, cytotoxic activity, anti-inflammatory activity, and neuroprotective activity.
