ABSTRACT
Drugs are chemical compounds or molecules that are employed in the treatment, diagnosis, and prevention of illness. Drug design or discovery is a labor-intensive procedure that takes a lot of time and money. This procedure has become a little simpler thanks to artificial intelligence (AI), which has also cut down on time and expense. Artificial intelligence is frequently utilised in polypharmacology, discovering molecular targets, lead compounds, predicting the mode of action of active molecules, and selecting populations for clinical trials. Chemical biology techniques can be used to improve the task of AI drug design. Chemical biology is the study of molecular activities occurring in living systems. It includes the use of some toolsets like chemical probes, phenotypic screening, antisense oligonucleotides, and many others. Chemical probes are small molecules with well-defined and targeted biological responses having strong affinity towards the target, high efficacy, and clearly defined pharmacological and biochemical profiles. Phenotypic screening is a method for finding molecules that can change a cell's phenotype. Similarly antisense oligonucleotides and RNAis are the molecules used to supress the expression of genes in human cells. These chemical biology technologies and AI can make the process of creating drugs less difficult and more sophisticated.
