ABSTRACT
The global outbreak of COVID-19, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a significant global health crisis. Among the primary features of COVID-19 is lung inflammation and respiratory failure driven by an overactive immune response known as a cytokine storm. In recent research, the renin-angiotensin system (RAS), which plays a crucial role in regulating various physiological functions, has emerged as a key player in COVID-19 pathogenesis. Notably, the angiotensin-converting enzyme 2 (ACE2), a component of the RAS, serves as the functional receptor and entry point for SARS-CoV-2.
