ABSTRACT
Drug–nutrient interactions manifest as the alteration of nutrient absorption, metabolism, excretion, or storage by drugs or, vice versa, as the modification of drug absorption, metabolism, excretion, or storage by nutrients. These intricate interplays transpire across a spectrum of substances, including pharmaceuticals, nonprescription medications, botanical supplements, and dietary components. Their ramifications span from mild perturbations to severe consequences, significantly influencing an individual’s well-being. These interactions may attenuate medication efficacy or heighten the risk of adverse reactions. Furthermore, they can precipitate nutrient imbalances or toxicities. Certain demographic groups, such as the elderly, prone to multi-medication regimens, face an augmented likelihood of these interactions, often exacerbated by age-related alterations in nutrient processing. Individuals grappling with chronic ailments like diabetes, kidney dysfunction, or liver disorders are predisposed to both nutrient deficiencies and medications susceptible to nutrient interactions. Pregnant and breastfeeding women, with their distinct nutritional requirements, are particularly vulnerable to such interactions. This chapter delves into the various facets of drug–nutrient interactions, elucidating their types, characteristics, and consequences, with a concurrent exploration of the underlying biochemical mechanisms governing these intricate relationships.
