ABSTRACT
Microbes or microbial enzymes can catalyze the synthesis of bioorganic compounds, and this process is defined as biocatalysis. Biocatalysis has become an essential technique in organic biotransformation, typically applied in chemical industries. Biocatalysts generally show high activity and excellent enantio, stereo, regio, and chemo-selectivity. They offer practical and cost-effective ways to synthesize semi-synthetic analogues and novel drug molecules. Many bacteria and fungi-derived enzymes could catalyze highly specific hydroxylations of various substrates that are highly complex to synthesize by chemical methods. This chapter details and discusses different biocatalytic microbial platforms that permit to produce the chiral drug intermediates.
