ABSTRACT
Over the years, owing to the adoption of scientific practices aquaculture industry has flourished and achieved new horizons of production; however, with progression, fish also became vulnerable to an array of pathogens, including aquatic organisms from cold water environment. Concurrently, the fish health management approaches have also advanced then also the episode of disease outbreaks are still frequent and widespread, and leading to fettered aquaculture production. The biotechnological approach has shown promising responses either to improve the health status of cultured organisms or to strengthen the diagnosis of diseases while safeguarding the aquatic environment. Such biotechnological interventions led to avoidance of the pathogen by strengthening the immune response of fish as well as avoiding any possible use of chemical remedial agents. Recently with the development of anti-microbial resistance and the emergence of superbugs, the employment of biocontrol strategy through biotechnology-based tools have gained momentum. The present chapter is a brief account of different biotechnological approach and their application in aquaculture to augment the immune response with appropriate disease diagnosis to achieve sustainable aquaculture production.
