ABSTRACT
Recently, the Danio rerio (zebrafish) has become a trending genetic model for the evolution of vertebrates, offering new research opportunities that are not readily available in other model organisms. The research with D. rerio has elucidated the molecular and cellular mechanisms underlying these biological processes. T-cell and thymic growth are strongly maintained mechanisms that have been throughout the evolution of vertebrates. D. rerio, like mammals, have an adaptive immune system composed of B lymphocytes, as well as the αβ and γδ lineages of T cells that form in the thymus. Zebrafish are a highly recommended research model since it has plenty of advantages over others such as easy and convenient manipulation of genome, rapid embryonic development, less generation time, external fertilization, etc. While using zebrafish as a prominent research tool, it is significant to consider the prevailing challenges. This review chapter points out identifying the similarities and differences between the immunobiology of D. rerio and mammalian T-cells, accentuating the benefits of using D. rerio 196as a genetic model to discover T-cell and thymic development, application of zebrafish as a promising research tool in the biomedical sector and prevailing challenges as well.
