ABSTRACT
Malaria continues to be the deadliest and most devastating parasite disease, killing billions of people each year in many tropical and subtropical nations. Plasmodium falciparum’s developing resistance to commonly accessible antimalarial medications is mostly to blame for the disease’s expanding impact. The creation of brand-new, affordable, and easily accessible antimalarial agents is essential. New antimalarial leads may come from tropical plant sources, as natural products have been crucial in identifying leads for creating medications to treat human ailments. The majority of the recently discovered plant-derived natural compounds with antiplasmodial and antimalarial activities are covered in this study. Use of the Artemisia annua plant species as artemisinin-based combination treatment can reduce the risk of drug resistance by combining them with other antimalarial effective medications (ACTs). This study also briefly examines new concepts that make use of plant genetic engineering technologies to create scalable, cost-effective, and effective malaria treatments. These organic and synthetic substances may help modern healthcare systems manage malaria infections, especially in developing countries, consequently lowering fatality rates.
