ABSTRACT
Malaria is an infectious disease that poses a serious public health risk to the entire world, with approximately 3 billion people living in endemic areas of more than 100 countries, 200 million additional cases of the illness reported annually, and roughly 1 million cases of illness fatalities in 2018. Malaria has been identified as a highly oxidative and inflammatory illness. As a crucial part of the host response against Plasmodium infection, the hosts create reactive oxygen species (ROS). Also, xanthine oxidase and other host oxidative enzymes are present in higher amounts in malaria patients. The elimination of the parasite is aided by increased reactive oxygen species generation, but too many of these ROS can cause inflammation and severely damages host cells and tissues, likely causing catastrophic illnesses. The eradication of malaria depends on the creation of novel, potent, affordable, and easy-to-use medications. In this situation, plant metabolites like artemisinin can replace current malaria medications because they prevent the spread of the disease. The ability to treat malaria infections with these herbal and man-made medications would aid modern healthcare systems in lowering the incidence of malaria fatalities, especially in developing countries.
