ABSTRACT
In December 2019, SARS-CoV-2 started spreading in China, subsequently causing a worldwide COVID-19 pandemic that affects various organs, predominantly respiration. Periodontitis, a chronic inflammation disease of periodontal tissues, also alters our systemic immune response. Consequently, periodontitis is presumed to play a part in COVID-19 severity. This research was conducted to ascertain different research methods implemented to determine periodontitis effects toward COVID-19 severity, and also blood parameters, biomarkers, and COVID-19 severity parameters which were significantly contrasting in COVID-19 patients with periodontitis. This scoping review was carried out utilizing the PRISMA diagram consisting of literature associated with COVID-19 patients as a population, the impact of periodontitis on COVID-19 severity as the concept, and a global context in several databases, including PubMed, WILEY, and Google Scholar. Five journals in line with the inclusion criteria applied confirmed various affiliations between periodontitis and COVID-19 severity. Journals included were one cross-sectional study, two cohorts, one case-control, and one analytical retrospective study. These studies stated that COVID-19 severity was predicated on several parameters, including blood parameters, biomarkers, hospitalization, mortality, ICU support, and ventilation assistance. Research methods implemented on periodontitis effects toward COVID-19 severity were case-control, cohort, cross-sectional, and analytical retrospective studies. Periodontitis aggravates COVID-19 severity as a result of increased parameters (D-dimer, troponin, CRP, pro-BNP, procalcitonin, HbA1c, ferritin, and WBC), consequently increasing hospitalization rate, mortality, ICU support, and ventilation assistance.
