ABSTRACT
Destruction in periodontitis is caused by alveolar bone loss and can result in tooth mobility until tooth loss. Growth factor has been widely used for tissue regeneration, including periodontal regeneration in periodontitis cases. The concentrated growth factor (CGF) is one of the derivatives from the platelet-rich fibrin (PRF) with the same 3-dimensional structure but with a more rigid structure and higher growth factors. To obtain some scientific data related to the use of CGFs for an infrabony defect in periodontitis treatment. This study was done using The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) to learn about the role of CGF in periodontal therapy. Five databases (EBSCO host, Pubmed, Scopus, Google Scholar, and Willey) were used from 2011 until July 2022. Initially, all the studies whose titles matched the search were found. All the Randomized-Clinical Trial (RCT) studies that have been filtered based on the inclusion and exclusion criteria were analyzed to find the use of CGF for infrabony defect treatment in periodontitis. CGF can be combined with bone graft material for periodontal regenerative therapy in infrabony defects in periodontitis surgical therapy.
